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Canadian women report serious Zofran side effects

February 27th, 2015

At least 20 Canadian women who were using Zofran during pregnancy gave birth to a child who experienced serious side effects, according the Toronto Star. A review of 2012 records found multiple cases of infants born with heart and kidney malformations, and at least two cases where the child died.

Many of the children born to mothers who used Zofran during pregnancy were also born critically underweight, some weighing as few as 4.5 pounds. Doctors also listed Zofran as the cause of several other birth defects in children, including musculoskeletal anomaly, cleft palate defects, jaundice, heart murmur and other heart defects.

As many as 15% of pregnant women take a drug to treat morning sickness, according to a recent study. Although Zofran has been prescribed by many doctors to treat morning sickness, it has not been approved by the U.S. Food and Drug Administration or Health Canada for use in pregnant women, and manufacturer GlaxoSmithKline has already paid more than $3 billion to settle lawsuits alleging it illegally promoted the drug for such uses.

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